Cardio Clear 7 Ingredients: The Three Named Actives

Coenzyme Q10 is a fat-soluble quinone the body makes for itself. It sits in the inner mitochondrial membrane and carries electrons between complexes of the respiratory chain, which is the process that turns food into adenosine triphosphate. Heart muscle contracts continuously and therefore holds one of the highest CoQ10 densities of any tissue in the body. That is why it appears in every serious heart formula, and it is a fact of biochemistry rather than a marketing line. NCCIH's page on coenzyme Q10 is the plainest neutral summary of it.

The clinical evidence is genuinely mixed, and it is worth having both halves. The Q-SYMBIO trial randomised 420 patients with moderate to severe heart failure to 100 mg of CoQ10 three times a day or to placebo, and reported fewer major adverse cardiovascular events and lower all-cause mortality in the CoQ10 arm over two years. That is a substantial result and it is the study every heart supplement page quotes. What those pages leave out is that the 2021 Cochrane review of CoQ10 for heart failure looked at the whole body of trials and concluded the evidence on mortality remains uncertain, and that the Cochrane review of CoQ10 for primary prevention found no completed trials reporting clinical outcomes in people without established disease.

For blood pressure the picture is similar. A Cochrane review of CoQ10 in primary hypertension found no convincing evidence of a blood-pressure-lowering effect, while a later dose-response meta-analysis in people with cardiometabolic disorders did report modest reductions. Gao 2012 reported improved flow-mediated dilation in a meta-analysis of endothelial function studies, and Dludla 2020 reviewed the metabolic and cardiovascular profile in diabetes. A 2021 review in Antioxidants pulls the strands together.

One more thing is worth saying because the search traffic for it is enormous. Statins inhibit HMG-CoA reductase, which sits upstream of both cholesterol and CoQ10 synthesis, so the depletion argument is biologically real. Whether supplementing helps muscle symptoms is contested: Qu 2018 reported benefit in a meta-analysis, Kennedy 2020 found no significant effect on myalgia scores, a 2025 systematic review revisited it, and the LIFESTAT study found statin treatment reduced mitochondrial respiration while muscle CoQ10 was unchanged. Derosa 2019 is a readable individual trial. Our blog post on CoQ10 and statins works through the disagreement properly.

Pyrroloquinoline quinone is a small redox-active quinone found in trace amounts in fermented soy, kiwi fruit, green peppers and human breast milk. It is sold as the disodium salt because that form is water-soluble and stable enough to put in a capsule. The marketing story is that PQQ promotes mitochondrial biogenesis, meaning the making of new mitochondria, and that a heart full of mitochondria should therefore benefit.

The human evidence is recent, small and about the brain. Tamakoshi 2023 gave 20 mg a day of PQQ disodium salt to younger and older adults and reported changes on cognitive testing. A 2024 randomised controlled trial used six weeks of a related dihydrogen form in older adults with mild cognitive impairment and measured mitochondrial biomarkers and brain metabolism alongside cognition. Both are interesting. Neither is about cardiovascular outcomes, and there is no trial on this ingredient that is.

Typical commercial PQQ supplements sit between 10 and 20 mg a capsule, which is roughly what the trials used, and PQQ is expensive enough that a formulator with a tight budget has an obvious incentive to use less of it. That is an argument, not a finding, and it is offered here as a reason to want the number rather than as a claim about what the number is.

This desk publishes what the bottle says and marks the gaps. The four claims below are the ones a sceptical reader can audit in ten minutes, which is the only reason to make them:

1. The bottle is the source. The two claim lines, the capsule count, the supply length and the serving instruction come from the printed label and the manufacturer’s own listing artwork, not from a review column.
2. The gaps are marked, never filled in. This label carries no amount for coenzyme Q10, for shilajit or for PQQ, and no price. Nothing undisclosed is estimated anywhere on this website, including in the schema a machine reads.
3. Sources are real and linked in the sentence. Every study cited here was confirmed against its PubMed record before it was written down, and the government pages were opened in a browser rather than assumed.
4. Corrections change the date. Write to [email protected] and the review date at the foot of the page moves forward.

We earn when you buy. Cardioclear7s is the Cardio Clear 7 retail desk named at the top of this page, and this website makes money on orders placed through it. That is exactly why the missing-amounts table, the three-star reviews and the page about the bonus reports are here: they are where our interest and yours pull apart, and you should be able to watch us choose.

The order desk on +1 (302) 200-3480 handles tracking, changes and refunds. It is not a sales line and this website never presents it as a way to place an order; orders go through the checkout only.

Written and reviewed by the Cardioclear7s Editorial Desk

Every page, every journal post, the bottle facts and the ingredients go through review by Dr. Brenda McCool, ND before they ship. We write these pages from the printed Cardio Clear 7 bottle and the manufacturer’s own listing artwork, cite public research for coenzyme Q10, shilajit and PQQ, and print “not published” wherever a figure is not disclosed rather than estimating it. This label publishes no amount for any of its three ingredients, and that fact appears on every page where an ingredient is named. Where the seller’s marketing claims more than the bottle supports, we say so on the page. Corrections are made on the page itself and the review date moves forward. Write to [email protected]. Last reviewed September 2026 by Dr. Brenda McCool, ND.